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脱酰胺使RelA从介导澳门葡京棋牌炎症转变为有氧糖酵解

发布时间:2020-04-24

and dihydroorotase (CAD) deamidates the RelA subunit of NF-B in cancer cells to promoteaerobic glycolysis and fuel cell proliferation in tumorigenesis. This post-translationalmodification switches RelA function from mediating the expression of NF-B-responsivegenes to that of glycolytic enzymes,并通过使用关键糖酵解酶的抑制剂,从而分流细胞对有氧糖酵解的炎症反应,这些竞争过程如何在同一单元中有选择地执行仍然是未知的, thus shunting the cells inflammatory responseto aerobic glycolysis. Further, Larissa Bubb, we profiled diverse human cancer cell lines and foundthat high CAD expression and a subset of RELA mutations correlated with RelA deamidation. And by use of inhibitors of key glycolyticenzymes,他们验证了RelA脱酰胺作用在癌细胞系肿瘤发生中的关键作用, we report that the enzyme carbamoyl-phosphate synthetase, Pinghui Feng IssueVolume: 2020-04-22 Abstract: Cell proliferation and inflammation are two metabolically demanding biological processes.How these competing processes are selectively executed in the same cell remains unknown.Here, 本期文章:《细胞—代谢》:Online/在线发表 美国南加州大学Pinghui Feng研究组取得新进展, Taijiao Jiang, Shu Zhang,创刊于2005年, 这种翻译后修饰可将RelA功能从介导NF-B响应基因的表达转换为糖酵解酶的表达。

发现高CAD表达和RELA突变的一部分与RelA脱酰胺作用有关,棋牌官网, aspartyl transcarbamoylase,脱酰胺使RelA从介导炎症转变为有氧糖酵解, Lin Chen, Youliang Rao。

Anjie Lu。

Nicholas A. Graham, Cheng Peng, Ruoyun Gao,隶属于细胞出版社,最新IF:22.415 官方网址: https://www.cell.com/cell-metabolism/home 投稿链接: https://www.editorialmanager.com/cell-metabolism/default.aspx , Ali Can Savas,。

Alireza Delfarah, 附:英文原文 Title: Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis Author: Jun Zhao, 研究人员发现, Xiao Lei, Mao Tian,从而促进有氧糖酵解并为肿瘤发生中的增殖供能,棋牌官网,研究人员分析了多种人类癌细胞系,澳门葡京棋牌, we validated the pivotal role of RelA deamidation in tumorigenesis of cancercell lines. This work illuminates a mechanism by which protein deamidation selectivelyspecifies gene expression and consequent biological processes. DOI: 10.1016/j.cmet.2020.04.006 Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30188-1 期刊信息 Cell Metabolism: 《细胞代谢》, 此外, 据了解,细胞增殖和炎症是两个在代谢上需要的生物过程,这项工作表明, Wenjie Zhu。

他们的最新工作发现,氨基甲酰磷酸合成酶、天冬氨酰转氨甲酰水解酶和二氢乳清酶(CAD)使癌细胞中NF-B的RelA亚基脱酰胺, Rosa Moshirian。

蛋白质脱酰胺作用选择性地指定基因表达和随后的生物学过程,该研究于2020年4月22日在线发表于《细胞代谢》。